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Year 2007, Month 4 (Section Reviews, Page 577)

Cage complexes of transition metals in biochemistry and medicine

Ya. Z. Voloshin,
O. A. Varzatskii, and Yu. N. Bubnov

The review presents the following main trends and the perspectives of application of the transition metal clathrochelates in medicine and biochemistry: encapsulation of radioactive metal ion for diagnostics and therapy; imaging agents for MRI; antidotes and prolonged pharmaceuticals; pharmaceuticals for boron neutron capture therapy; antihelminthic and antiparasitic detergents; antioxidants; membrane transport of the metal ions; interaction of the cage metal complexes with nucleic acids and the potential of their self
assembling reactions in immunology and molecular biology (recognition of antibodies, antigens and DNA sites); design of HIV inhibitors for the therapy.

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