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Year 2007, Month 4 (Section Reviews, Page 631)

Redox reactions of natural alkaloid lappaconitine

N. E. Polyakov and T. V. Leshina

A review on redox reactions of natural alkaloid lappaconitine, a known sodium channel blocker, is presented. The NMR and CIDNP data on the mechanism of phototransformation of lappaconitine, in particular, of its paramagnetic species formed by both the direct photolysis and photoinitiated interaction with electron donors and acceptors, are analyzed. Special atten
tion is given to the interaction of lappaconitine with amino acids, which are present in the active site of the sodium channel. Hypotheses about a relationship between this process and the mechanism of therapeutic activity of lappaconitine are discussed.

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