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Year 2007, Month 4 (Section Full Articles, Page 754)

Reduction of nitrates, the NO donors, by hemoglobin in the presence of cysteine

L. A. Syrtsova,
A. I. Kotel´nikov, B. L. Psikha, E. S. Malkova, N. I. Shkondina, and E. I. Gainullina

Hemoglobin (Hb) reduces 3,3-bis(nitroxymethyl)oxetane (NMO) only in the presence of cysteine (Cys) via intermediate cysteine thionitrate. The kinetics of the reaction of NMO with Cys and the kinetics and mechanism of formation of NO in the ternary system Hb—NMO—Cys were studied. The formation rate of Hb—NO in the ternary system is higher than that of Hb—NO in the reaction of Hb only with NO2 – generated in the binary system NMO—Cys. The second
order rate constants of the main reaction steps in the system Hb—NMO—Cys were estimated by simulating the kinetics of the reactions with a system of equations taking into account equilibria between all components of the reaction mixture. Hemoglobin reduces cysteine thionitrate, the intermediate in the reaction of NMO with Cys, to NO.

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