ISSUE 1

ISSUE 2

ISSUE 3

ISSUE 4

ISSUE 5

ISSUE 6

ISSUE 7

ISSUE 8

ISSUE 9

ISSUE 10

ISSUE 11

ISSUE 12

ISSUE 4

Year 2007, Month 4 (Section Full Articles, Page 761)

Hemoglobin
stabilized tetranitrosyl binuclear iron complex with pyridin-2-yl in aqueous solutions

N. A. Sanina,
L. A. Syrtsova, N. I. Shkondina, E. S. Malkova, A. I. Kotel´nikov, and S. M. Aldoshin

The tetranitrosyl iron complex with pyridin
2
yl [Fe2(SC5H4N)2(NO)4] (1) has higher NO-donating activity in 3% aqueous solutions of DMSO (pH 7.0, 25 °C) than the organic NO donor, viz., adduct of NO with diethylenetriamine (NO-adduct). The NO concentration was determined by the spectrophotometric method based on the formation of an NO complex with hemoglobin (Hb). The apparent first
order rate constants of the studied reactions are (6.15±0.6)•10–1 s–1 and (0.8±0.08)•10–1 s–1 for complex 1 and the NO-adduct, respectively, at an Hb concentration of 2•10–1 mol L–1 and the ratio [NO donor]/[Hb] = 10. The effect of Hb and [NO donor]/[Hb] ratio on the rate of NO generation from a solution of complex 1 was studied. For a fourfold decrease in the concentration of complex 1 the reaction rate constant decreases to 0.5•10–4 s–1, whereas the fourfold increase in the Hb concentration results in the stabilization of complex 1.

BACK   I wish to order PDF file of this article for 25.00 USD