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Year 2007, Month 4 (Section Full Articles, Page 767)

Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine

M. N. Xanthopoulou, S. K. Hadjikakou,
N. Hadjiliadis, N. Kourkoumelis, E. R. Milaeva,
Yu. A. Gracheva, V. Yu. Tyurin, I. Verginadis, S. Karkabounas, M. Baril, and I. S. Butler

The known organotin(IV) complexes with 2-mercaptopyrimidine (L) [Me2SnL2] (1), [Bun 2SnL2] (2), [Ph2SnL2] (3), and [Ph3SnL] (4) were synthesized using a new approach. The effect of the synthesized compounds on peroxidation of fatty acids (oleic and linoleic) was studied. Complexes 1—4 promote the peroxidation of oleic acid. Their effect on the enzymatic peroxidation of linoleic acid with lipoxygenase was compared with that of cisplatin and in vitro cytoxicity against sarcoma cancer cells was determined. The antiproliferative effect of com
plexes 2—4 was demonstrated.

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