Year 2007, Month 10 (Section Full Articles, Page 2034)
Synthesis of 2-alkyl-2-(3-cyanopyridin-2-ylthio)propionic acids
V. K. Zav´alova, A. A. Zubarev, and V. P. Litvinov
Derivatives of 2-alkyl-2-mercaptopropionic acid were synthesized based on the substituted 3-cyanopyridin-2(1H )-thiones. The synthesis was carried out by the heating of a mixture of thione, alkyl methyl ketone, and chloroform in the presence of a base. The reaction proceeds readily for acetone, whereas alkyl methyl ketones require a prolonged heating in the presence of a phase-transfer catalyst. Methyl esters were prepared from the acids obtained.
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