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Year 2007, Month 10 (Section Full Articles, Page 2109)

Four new chamigrane sesquiterpenoids from the opistobranch mollusk Aplysia dactylomela

L. K. Shubina, S. N. Fedorov, A. I. Kalinovskiy, A. S. Dmitrenok, J. O. Jin, M. G. Song, J. Y. Kwak, and V. A. Stonik

Four new chamigrane sesquiterpenoids, (6S,10S)-10-bromo-3,11,11-trimethyl-7-methylidenespiro[5.5]undec-2-ene-4-one, (4S,6S,10S)-10-bromo-3,11,11-trimethyl-7-methylidenespiro[5.5]undec-2-ene-4-ol, (3R,4S,6S,10R)-10-bromo-3,11,11-trimethyl-7-methylidenespiro[5.5]undecane-3,4-diol, and (6S,7S,11R)-2-chloro-3,7,11-trimethyl-10-methylidenespiro[5.5]undec-2-ene-7-ol, were isolated from the sea hare Aplysia dactylomela. The chemical structures of new compounds were established by NMR spectroscopy and mass spectrometry. The cytotoxic activity of some of the obtained compounds against promyelocytic HL-60 and monocytic THP-1 leukemia cells was demonstrated.

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