Year 2007, Month 12 (Section Full Articles, Page 2456)
Synthesis of N-(2-chloroethyl)glycine and -DL-alanine esters
I. M. Aladzheva, O. V. Bykhovskaya, P. V. Petrovskii, and T. A. Mastryukova
Two methods for the synthesis of N-(2-chloroethyl)glycine and -DL-alanine esters are proposed: 1) reductive àmination of the C=O group of glyoxilic or pyruvic acids upon treatment with 2-chloroethylàmine and sodium cyanoborohydride in methanol and 2) alkylation of 2-chloroethylàmine with α-haloalkanoic acid esters in K2CO3—MeCN two-phase system.
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