Year 2007, Month 12 (Section Full Articles, Page 2499)
Nonenzymatic recombination of RNA by means of transesterification
A. V. Lutay, I. V. Grigoriev, M. A. Zenkova, E. L. Chernolovskaya, and V. V. Vlassov
Coupled nonenzymatic cleavage/ligation of oligoribonucleotides catalyzed by magnesium ions afforded longer RNA molecules with a new sequence. The efficiency of formation of ligation products reaches 6%. The possible role of this reaction in the evolution of the RNA world is discussed.
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