Year 2005, Month 5 (Section Full Articles, Page 1189)
Synthesis of 3,5-disubstituted 4-aminoisoxazoles by cyclization of
O(β-oxoalkyl)-substituted α-hydroxyimino nitriles
V. P. Kislyi, E. B. Danilova, and V. V. Semenov
4-Amino-5-benzoyl(acetyl)isoxazole-3-carboxamides were prepared by cyclization of
α-hydroxyimino nitriles O-alkylated with bromoacetophenones (bromoacetone). The purity of
the target 4-aminoisoxazoles can be substantially increased by treating O-alkylated oximes with
LiClO4 before cyclization.
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