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Year 2005, Month 5 (Section Brief Communications, Page 1340)

Reduction of (E )-3-aryl-2-(thiazol-2-yl)acrylonitriles with lithium aluminum hydride*

K. A. Frolov (a), V. V. Dotsenko (a), S. G. Krivokolysko (a), A. N. Chernega (b), and V. P. Litvinov (c)

Reduction of (E)-3-aryl-2-(4-arylthiazol-2-yl)acrylonitriles with lithium aluminum hydride in dry ether afforded (Z )-1-amino-3-aryl-2-(thiazol-2-yl)prop-1-ene derivatives in 15 to 40% yields. The structure of (Z )-1-amino-3-(2-chlorophenyl)-2-[4-(4-methylphenyl)thiazol-2-yl]prop-1-ene was confirmed by X-ray diffraction analysis.

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